General description
A thienopyridinone compound that inhibits UCH-L1-catalyzed substrate hydrolysis (Ki app = 2.8 µM with Ub-AMC as the substrate) in an uncompetitive manner by targeting the enzyme-substrate complex, but not the free enzyme, while exhibiting little activity against UCH-L3, TGase 2, Papain, or Caspase-3 even at concentrations as high as 20 µM.
The UCH-L1 Inhibitor II, also referenced under CAS 439946-22-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Mermerian, A.H., et al. 2007. Bioorg. Med. Chem. Lett.17, 3729.
Packaging
Packaged under inert gas
10 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Warning
Toxicity: Standard Handling (A)
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